BOSTON — Balitmore Orioles third baseman Manny Machado went into an epic profanity-laden tirade Tuesday night after Boston Red Sox ace Chris Sale threw behind him, saying he has lost all respect for the Red Sox organization.

“It’s (expletive) … ’’ Machado said after the Red Sox’s 5-2 victory. “It’s coward stuff. I mean, that stuff you don’t (expletive) do, but I’m not that side. I’m not in that organization.

“I’ve lost my respect for that organization, for that coaching staff, for everyone over there.’’

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Sale’s first pitch to Machado in the first inning was thrown behind him, in retaliation to Orioles pitcher Dylan Bundy hitting Red Sox outfielder Mookie Betts on Monday, in retaliation to Red Sox reliever Matt Barnes throwing at Machado’s head on Sunday, and in retaliation to Machado’s hard slide on Friday that injured Red Sox second baseman Dustin Pedroia.

Home-plate umpire D.J. Reyburn immediately issued a warning to both benches, letting them know the next one to throw a purpose pitch would be ejected, infuriating Orioles manager Buck Showalter.

“They’re still thinking the slide that I did when I had no intention of hurting anybody,’’ Machado said. “And I’m still trying to get hit at. Thrown at my (expletive) head. (Expletive) thrown at everywhere. (Expletive) bull …

“If you’re going to (expletive) hit me, go ahead, (expletive) hit me. You know, don’t let (expletive) keep lingering around and (expletive) around. Keep (expletive) trying to hit people. That’s (expletive) bull.

“MLB should do something about it. (Expletive) pitchers go out there with their (expletive) balls in their hand and throwing 100 mph trying to hit people. I got a (expletive) bat too. I can go up there and crush somebody if I wanted to, but you know what, I’ll get suspended for the year and the pitcher will only get suspended for two games.

“That’s not cool. That’s not cool.’’

Sale, 2-2, 1.38 ERA, said he simply was trying to be competitive while Red Sox manager John Farrell insisted it was simply a pitch that got away.

“He was going in with a fastball and pulled it in,’’ Farrell said. “He threw 115 pitches tonight. I don’t know that you can hit the spot every single time you throw the baseball.’’

Certainly, no one on the Orioles bought it, least of all Machado, who was asked whether he believed Sale should be suspended.

“I don’t know, that’s not my call,’’ Machado said. “I play baseball. That’s all I can control. They got to do something about it. If you’re going to hit somebody, go ahead and hit them. It’s (expletive) bull …’’

When asked why he continued to be targeted by the Red Sox pitching staff, Machado directed the questions to the Red Sox.

“Go (expletive) ask Farrell, I don’t know,’’ he said. “For me, the way I see it, I slid into second base normal, and I kind of hurt (Pedroia) a little bit, unintentional. And they’re still trying to make me pay for it.

“I don’t know what they’re trying to pay for. I don’t know what their mindset is. Whatever. I’m just preparing to play baseball, trying to win games for my team and that’s all I can control.’’

Machado got his revenge in the seventh inning when he homered off Sale, his sixth of the season, but it was hardly enough to soothe him.

“Probably not the best move,’’ Orioles teammate Adam Jones said of Sale’s pitch. “I do know he’s going to protect his players. Good thing he didn’t hit him. That was 97 [mph], that wouldn’t have felt good.

“No way am I going to allow that stuff to happen to the best player on our team. He handled it properly. He went deep later, and showed his way of retaliation.

“At the end of the day, the best way to speak in this game is with your bat, you’re glove, and not with your mouth.’’

The two teams resume the series Wednesday night at Fenway Park, completing the four-game series Thursday, and still have 10 games against one another this season.

Stay tuned.

It’s a feud that refuses to go away.

Follow Bob Nightengale on Twitter and on Facebook.

PHOTOS: Player and manager ejections

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