Phoenix police Sgt. Alan Pfohl describes the two-vehicle crash that killed one and injured three on April 20, 2017. Rebecca Dantuono/

A second person has died following “a horrific car crash” that also injured two children Thursday evening in Phoenix, and officials say a medical emergency may have preceded the collision.

The driver of a sedan that collided head-on with a pickup truck died at a hospital overnight, police said Friday. A 25-year-old woman in his vehicle was pronounced dead at the scene, and two children who were sitting in the back seat were injured and remain hospitalized.

Sgt. Alan Pfohl, a Phoenix police spokesman, said investigators have since learned that the sedan’s driver, a 34-year-old man,┬áhad “a medical history and it’s possible he was having a medical event at the time of the collision.”

Police have not released the names of the deceased.

The crash occurred at about 4:40 p.m. just south of the intersection of 32nd Street and Paradise Lane. Police say the sedan was driving southbound on 32nd Street at a “higher than normal” speed when it entered the two-way left turn lane and crashed head-on with the pickup.

An 8-year-old girl in the back seat of the sedan remained in extremely critical condition Friday, Pfohl said. A 3-year-old boy who had been sitting in a car seat next to her was in serious but stable condition.

The driver of the truck, a 49-year-old man, suffered only minor injuries.

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